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个人信息

   名: 张爱东

   历: 研究生(博士)

   称:  

   话: 027 67867635

E-mailadzhang@mail.ccnu.edu.cn


教育与工作经历

现任bevictor伟德官网教授、博士生导师;学术兼职:国家工信部禁止化学武器履约专家兼翻译,湖北省监控化学品协会副秘书长。

1984.7-1988.6:兰州大学有机化学专业学习,获得理学学士学位;

1988.7-1991.6:武汉大学有机化学专业学习,获得理学硕士学位;

1995.9-1998.10:武汉大学有机化学专业学习,获得理学博士学位;

2000.9-12法国里昂中央理工大学表面功能化实验室博士后;

2001.1-12以色列巴伊兰大学化学系博士后;

2005.9-11:法国里昂中央理工大学邀请教授;

1991.7-至今:bevictor伟德官网教师,先后任助教(1991.7-1993.10)、讲师(1993.11- 1996.9)、副教授(1996.10-2002.9)、教授(2002.10-)、博士生导师(2004.10-


研究领域与兴趣

1. 有机合成化学:具有生物活性的化合物合成方法和生物活性研究;

2. 高分子化学与材料:特殊单体和高分子材料设计合成及其功能特性研究。


承担项目与课题信息

1. 国家自然科学基金MEP途径DXR酶双底物抑制剂的靶向设计合成和生物活性研究, 2023-202654万元,项目负责人;

2. 国家重点研发计划项目:智能控释材料分子设计及纳米农药研制, 2023-202875万元,子课题负责人;

3. 教育部装备预研联合基金项目:*********材料研究,2018-2020100万元,项目负责人;

4. 国家自然科学基金:基于含氟衍生化和前药化策略的天然产物结构优化与除草剂发现, 2018-202164万元,项目负责人;

5. 国家自然科学基金MEP途径IspD酶抑制剂先导结构化合物的设计合成和生物活性研究, 2015-201886万元,项目负责人;

6. 武汉市科技计划项目:低介电含氟环氧树脂电子封装材料研究, 2018-202050万元,项目负责人。


学术成果(代表性论文)

1. Wu, X.; Yang, Z.; Song, C.; Bu, M.; Li, W.; Duan, J.;* Yang, G. F.; Zhang, A.* Hydroxamate-Containing Bisphosphonates as Fosmidomycin Analogues: Design, Synthesis, and Proherbicide Activity. J. Agric. Food Chem. 2024, 72 (14), 7684–7693.

2. Wu, X.; Bu, M.; Yang, Z.; Ping, H.; Song, C.; Duan, J.;* Zhang, A.* Design and synthesis of fosmidomycin analogs containing aza-linkers and their biological activity evaluation. Pest Manag. Sci. 2024, 80, 846–856.

3. Wu, X.; Ping, H.; Song, C.; Duan, J.; Zhang, A. Optimization synthesis of phosphorous-containing natural products fosmidomycin and FR900098. Phosphorus Sulfur. 2023, 198 (5), 446-452.

4. Wu, X.; Yang, Z.; Bu, M.; Duan, J.; Zhang, A. Design, Synthesis and Bioactivity Evaluation of Heterocycle-Containing Mono- and Bisphosphonic Acid Compounds. Molecules 2023, 28 (22), 7509.

5. Duan, J.; Mei, C.; Wu, W.; Rao, L.; Fan, H.; Tang, Y.; Zhang, A. Disilyl Bis(Secondary Amine)-Enabled Epoxy Ring-Opening and Silylotropic N → O Migration Leading to Low Dielectric Epoxy Copolymers. Macromolecules 2021, 54 (14), 6947-6955.

6. Wang, J.; Zhou, Y.; Wang, X.; Duan, L.; Duan, J.; Li, W.; Zhang, A. Synthesis and Evaluation of Halogenated 5-(2-Hydroxyphenyl)pyrazoles as Pseudilin Analogues Targeting the Enzyme IspD in the Methylerythritol Phosphate Pathway. J Agric Food Chem 2020, 68 (10), 3071-3078.

7. Nuer, M.; Duan, J.; Wei, Z.; Wu, W.; Ma, J.; Zhang, A. Fluorocarbon-hydrocarbon hybrid cationic surfactants: Synthesis, surface-activity properties and anti-corrosion performance. J. Mol. Liq., 2020, 306, 112, 112987.

8. Z. Wei, X. Chen, J. Duan, G. Zhan, Y. Wei, A. Zhang. Branched chain versus straight chain fluorinated surfactant: A comparative study of their anticorrosion performance on carbon steel. J. Mol. Liq., 2019, 280, 327–333.

9. Z. Wei, X. Chen, J. Duan,* C. Mei, D. Xiao and A. Zhang. Precision synthesis of 3-substituted urushiol analogues and the realization of their urushiol-like performance. RSC Adv., 2019, 9, 24904–24914.

10. Duan, J.; Wu, W.; Wei, Z.; Zhu, D.; Tu, H.; Zhang, A. Synthesis of functional catechols as monomers of mussel-inspired biomimetic polymers. Green Chemistry 2018, 20 (4), 912-920.

11. Wu, W.-H.; Duan, J.; Wei, T.; Tu, H.-Y.; Zhang, A.-D. The role of β-cyclodextrin in mediating regioselective dimethylaminomethylation of phenol. Tetrahedron 2018, 74 (2), 360-365.

12. Wang, X.; Chen, R. X.; Wei, Z. F.; Zhang, C. Y.; Tu, H. Y.; Zhang, A. D. Chemoselective Transformation of Diarylethanones to Arylmethanoic Acids and Diarylmethanones and Mechanistic Insights. J. Org. Chem. 2016, 81 (1), 238-249.