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Associate Professor

    REN Yanliang

    Chinese Version  (中文版)

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    1998.9 –2002.7, Bachelor Degree in Chemistry, Department of Chemistry,Datong University, P. R. China

    2002.9 –2007.7, Doctor Degree in Organic Chemistry, College of Chemistry, Central China Normal University, P. R. China

    2008.1-2012.6, Lecturer, College of Chemistry, Central China Normal University, P. R. China

    2008.4 –2009.4, Postdoctoral research, Kyushu University

    2012.7 –present, Associated Professor, College of Chemistry, Central China Normal University, P. R. China

    Research Fields and Interests

    My main interestis to develop novel drugs for medicinal purposes through rational design by jointlyusing computational techniques, such as molecular docking, molecular dynamics, quantum chemistry methods etc, synthesis and enzymatic assays.

    I am also employingand developing a variety of state-of-the-art computational approaches(Semi-empirical MO Methods, Ab initioMethods, ElectronicDensity-Functional Theory, Hybrid Methods, Molecular Simulation Methods) to theoretically study on the Molecular Spectroscopic Properties (Absorptionaland Circular Dichroism Spectra)and Mechanism of enzymes catalysereactions of various Chemical and Biological Systems, Molecular-Structure/Macroscale Property correlations like QSARs and QSPRs, and Structure-based Drug Design.

    Selected Publications

    1. Xinya Han, Xiuyun zhu, Shuaihua zhu, Lin Wei, Zongqin Hong, Li Guo, Haifeng Chen, Bo Chi, Yan Liu, Lingling Feng,Yanliang Ren* and Jian Wan* A Rational Design, Synthesis, Biological Evaluation and Structure-Activity Relationship Study of  Novel Inhibitors against Cyanobacterial Fructose-1, 6-Bisphosphate Aldolase." J. Chem. Inf. Model. 2016, 56, 73-81.

    2.Yanliang Ren, Osama Melhem, Yongjian Li, Bo Chi, Xinya Han, Hao Zhu, Lingling Feng, Jian Wan,* Xin Xu* Clarifying and Illustrating the Electronic Energy Transfer Pathways in Trimeric and Hexameric Aggregation State of  Cyanobacteria Allophycocyanin with in the Framework of Forster Theory, J.Comput. Chem. 2015, 36, 137-145 (Cover Paper)

    3. Ding Li , Xinya han ,Qidong tu , Lingling Feng , Di Wu , Yao Sun , Haifeng Chen , Yongjian Li ,Yanliang Ren,*and Jian Wan.* Structure-Based Design and Synthesis of Novel Dual-target inhibitors against Cyanobacterial Fructose-1, 6-Bisphosphate Aldolase and Fructose-1, 6-Bisphosphatase.J. Agric. Food Chem.2013,61, 7453–7461.

    4.Yanliang Ren,Bo Chi, Melhem Osama, Wei Ke, Lingling Feng, Yongjian Li, Xinya Han, Ding Li, Yang Zhang, Jian Wan.* and Xin Xu.*Yang Minghui, Understanding the Electronic Energy Transfer Pathways in the Trimeric and Hexameric Aggregation State of Cyanobacteria Phycocyanin withinthe Framework of Förster Theory, J. Comput. Chem. 2013, 34, 1005-1012. (Inside Cover Paper).

    5. Ding Li, Jie Gui, Yongjian Li, Lingling Feng, Xin a Han, Yao Sun, Tinglin Sun, Zhigang Chen, Yi Cao, Yang Zhang, Li Zhou, Xiaopeng Hu,Yanliang Ren,*Jian Wan,* Structure-Based Design and Screen of  Novel Inhibitors for Class II3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Streptococcus Pneumoniae,J. Chem. Inf. Model., 2012, 52, 1833–1841.

    6.YanliangRen, Junbo He, J.; Feng, L.; Liao, X.; Jin, J.; Li, Y.; Cao, Y.; Wan, J.; He, H. Structure-based rational design of novel hit compoundsfor pyruvate dehydrogenase multienzyme complex E1 components from Escherichiacoli. Bioorg. Med. Chem. 2011, 19, 7501-7506.

    7. Minggui Yuan, Minxian Luo, Yao Song, Qiu Xu, Xiaofeng Wang, Yi Cao, Xianzhang Bu*,Yanliang Ren*and Hu, Xiao peng. Identification of curcumin derivatives as human Glyoxalase Iinhibitors: A combination of Biological Evaluation, Molecular Docking, 3D-QSAR and Molecular Dynamics Simulation studies, Bioorg. Med. Chem. 2011, 19, 1189.

    8. Qingye Zhang, Ding Li, Pei Wei, Jie Zhang, Jian Wan*, Yangliang Ren, Zhigang Chen, Deli Liu, Ziniu Yu, Lingling Feng*. Structure-based Rational Screening of Novel Hit Compounds with Structural Diversity for Cytochrome P450 Sterol 14a-demethylase from Penicillium digitatum, J. Chem. Inf. Model., 2010, 50, 317-325.

    9.Yanliang Ren, Wei Ke, Yongjian Li, Lingling Feng, Jian Wan, Xin Xu. Understanding the Spectroscopic Properties of the Photosynthetic Reaction Center of Rhodobacter sphaeroides by a Combined Theoretical Study of Absorption and Circular Dichroism Spectra,J. Phys. Chem. B, 2009, 113, 10055–10058.

    Address: Wuhan city Hongshan District Luoyu Road No. 152 Chemical building of Central China Normal University 430079 Tel: 027-67867955 Copyright 2015 - 2020 bevictor伟德官网(中国)股份有限公司 -Unique Platform